Long-Term Kidney Outcomes in High BMI Living Kidney Donors: A Narrative Review
Kalyani Murthy*, 1, 2, Hannah Caldwell1, Mary A. Simpson3
Identifiers and Pagination:Year: 2017
First Page: 41
Last Page: 51
Publisher Id: TOUNJ-10-41
Article History:Received Date: 07/06/2017
Revision Received Date: 20/09/2017
Acceptance Date: 29/09/2017
Electronic publication date: 24/10/2017
Collection year: 2017
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The shortage of transplantable organs has led to the expansion of the living kidney donor (LKD) pool to include overweight (body mass index [BMI] 25-30 kg/m2) and obese (BMI ≥30 kg/m2) donors. Higher BMI is a known risk factor for chronic kidney disease and progression to end-stage renal disease.
Methods & Materials:
We focused our review on long-term kidney-related outcomes (kidney function, hypertension, and proteinuria) among higher BMI LKDs. A PubMed search retrieved a total of 27 articles reporting on renal outcomes for obese LKDs. Of these, nine studies with ≥5 years of follow-up were selected for inclusion.
Five studies reported a decrease in kidney function at follow-up for higher BMI LKDs. Higher BMI was noted as a risk factor for hypertension in six studies. Proteinuria was reported in six studies, and a significant association was noted with higher BMI status in three.
This review highlights the continued need for long-term documentation of kidney function and related outcomes in higher BMI LKDs.