Long-Term Kidney Outcomes in High BMI Living Kidney Donors: A Narrative Review

Murthy, Kalyani; Caldwell, Hannah; Simpson, Mary A.

Long-Term Kidney Outcomes in High BMI Living Kidney Donors: A Narrative Review

Kalyani Murthy^{*, 1, 2}, Hannah Caldwell¹, Mary A. Simpson³

¹ Department of General Internal Medicine, Lahey Hospital & Medical Center, Burlington, MA, USA

² Associate Clinical Professor, Tufts University School of Medicine, Boston, MA, USA

³ Director, Clinical Research & Education (Transplantation), Lahey Hospital & Medical Center, Burlington, MA, USA

Article Information

Identifiers and Pagination:

Year: 2017
Volume: 10
First Page: 41
Last Page: 51
Publisher ID: TOUNJ-10-41
DOI: 10.2174/1874303X01710010041

Article History:

Received Date: 07/06/2017
Revision Received Date: 20/09/2017
Acceptance Date: 29/09/2017
Electronic publication date: 24/10/2017
Collection year: 2017

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© 2017 Kalyani Murthy.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

^* Address correspondence to this author at the Department of General Internal Medicine, Lahey Hospital and Medical Center, 41 Mall Road, Burlington, MA, 01805, USA; Tel: 7817441956; Fax: 7817445372; E-mail: Kalyani.Murthy@Lahey.org

Background:

The shortage of transplantable organs has led to the expansion of the living kidney donor (LKD) pool to include overweight (body mass index [BMI] 25-30 kg/m2) and obese (BMI ≥30 kg/m2) donors. Higher BMI is a known risk factor for chronic kidney disease and progression to end-stage renal disease.

Methods & Materials:

We focused our review on long-term kidney-related outcomes (kidney function, hypertension, and proteinuria) among higher BMI LKDs. A PubMed search retrieved a total of 27 articles reporting on renal outcomes for obese LKDs. Of these, nine studies with ≥5 years of follow-up were selected for inclusion.

Results:

Five studies reported a decrease in kidney function at follow-up for higher BMI LKDs. Higher BMI was noted as a risk factor for hypertension in six studies. Proteinuria was reported in six studies, and a significant association was noted with higher BMI status in three.

Conclusion:

This review highlights the continued need for long-term documentation of kidney function and related outcomes in higher BMI LKDs.

Keywords: living kidney donors, obesity, overweight, kidney function, chronic kidney disease, hypertension.

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Hernandes F. de Carvalho
Institute of Biology
State University of Campinas
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Long-Term Kidney Outcomes in High BMI Living Kidney Donors: A Narrative Review

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