REVIEW ARTICLE
Long-Term Kidney Outcomes in High BMI Living Kidney Donors: A Narrative Review
Kalyani Murthy*, 1, 2, Hannah Caldwell1, Mary A. Simpson3
Article Information
Identifiers and Pagination:
Year: 2017Volume: 10
First Page: 41
Last Page: 51
Publisher ID: TOUNJ-10-41
DOI: 10.2174/1874303X01710010041
Article History:
Received Date: 07/06/2017Revision Received Date: 20/09/2017
Acceptance Date: 29/09/2017
Electronic publication date: 24/10/2017
Collection year: 2017

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Background:
The shortage of transplantable organs has led to the expansion of the living kidney donor (LKD) pool to include overweight (body mass index [BMI] 25-30 kg/m2) and obese (BMI ≥30 kg/m2) donors. Higher BMI is a known risk factor for chronic kidney disease and progression to end-stage renal disease.
Methods & Materials:
We focused our review on long-term kidney-related outcomes (kidney function, hypertension, and proteinuria) among higher BMI LKDs. A PubMed search retrieved a total of 27 articles reporting on renal outcomes for obese LKDs. Of these, nine studies with ≥5 years of follow-up were selected for inclusion.
Results:
Five studies reported a decrease in kidney function at follow-up for higher BMI LKDs. Higher BMI was noted as a risk factor for hypertension in six studies. Proteinuria was reported in six studies, and a significant association was noted with higher BMI status in three.
Conclusion:
This review highlights the continued need for long-term documentation of kidney function and related outcomes in higher BMI LKDs.