RESEARCH ARTICLE


Plasma Concentration of Galanin in Chronic Hemodialysis Patients



Ioannis Legakis1, *, Vasilliki Dardioti 2, Spyros Moutafis2
1 Department of Endocrinology and Metabolism
2 Department of Nephrology, Henry Dunant Hospital, Athens, Greece


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© Legakis et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the “Henry Dunant” Hospital, 33 Alimousion Street, Thision, 11851, Athens, Greece; Tel: #30 1 6526655; Tel: #30 1 7772253; E-mail: ilegak@med.uoa.gr


Abstract

Galanin has diverse physiological functions, including nociception, arousal/sleep regulation, congnition, and many aspects of neuroendocrine activities that are associated with feeding, energy metabolism, thermoregulation, osmotic and water balance, and reproduction.

In an attempt to clarify the metabolic profile of circulating galanin in blood, we examined plasma galanin concentration in patients with end-stage renal disease undergone hemodialysis. Our data document that galanin levels were reduced compare to post-dialysis levels and highlight an altered metabolic profile of galanin in renal failure.

Keywords : Plasma concentration, galanin, chronic hemodialysis, patients..