Sympathetic Renal Denervation for the Treatment of Hypertension: A Review of Current Progress, Limitations, Techniques, and the Future

Tushar Sharma*, Anjay Rastogi, Rishi Talwar, Reza Khosravani Goshtaseb, Rohit Kumar , Mohamad Rashid
Research Department, Division of Nephrology, University of California, Los Angeles, USA

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© Sharma et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Research Department, Division of Nephrology, University of California, Los Angeles, USA; Tel: 310-954-2692; Fax: 310-474-0725; E-mail:


Although the etiology of hypertension is complicated and multifactorial, the role of sympathetic overactivity as part of the pathogenesis in essential hypertension has been well described in the literature. A promising new treatment modality of Renal Sympathetic Denervation has become prominent with very enthusiastic support. This paper suggests that while the support may be overhyped, this new treatment modality may, with further research, become a powerful tool for a specific patient population. The history, benefits, and limitations of the procedure are discussed including, but not limited to, proper screening methodology, technical aspects, and procedural complications.

Keywords: Hypertension, refractory hypertension, secondary hypertension, sympathetic denervation..