Long-Term Results of Radical Surgery and Adjuvant Radiotherapy in a Case of Primary Malignant Fibrous Histiocytoma of the Kidney

Luigi Cormio1, *, Francesca Sanguedolce2, Paolo Massenio1, Giuseppe Di Fino1, Giuseppe Lucarelli1, Vito Mancini1, Pantaleo Bufo2, Giuseppe Carrieri1
1 Department of Urology and Renal Transplantation, University of Foggia, Foggia, Italy
2 Department of Pathology, University of Foggia, Foggia, Italy

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© Cormio et al.; Licensee Bentham Open

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at theDepartment of Urology and Renal Transplantation, University of Foggia, Viale Luigi Pinto 1, 71121 Foggia, Italy; Tel: +393208584073; E-mail:


Malignant fibrous histiocytoma of the kidney is an extremely rare tumor that isthought to arise from the renal capsule. Radical nephrectomy is the standard treatment for localized disease but 25% of patients die of metastatic disease despite radical surgical resection. In the absence of clear pathogenetic information, adjuvant treatment remains empiric. Herein, we describe the case of a previously healthy 58-year-old woman who underwent radical nephrectomy because of 8-cm solid lesion of the right kidney; pathology revealed a pleomorphic malignant fibrous histiocytoma invading the perinephric fat, stage pT3aN0. She received adjuvant radiotherapy. To date, five years after surgery, she is alive and there is no evidence of disease. To our knowledge, this is the first report of favorable long-term results of surgery and adjuvant radiotherapy in a locally-advanced malignant fibrous histiocytoma of the kidney.

Keywords: Adjuvant radiotherapy, histiocytoma, kidney, long-term, radical surgery, rare tumor.