RESEARCH ARTICLE


Vascular Access Calcification and Arteriovenous Fistula Maturation



Timmy Lee*
Department of Medicine, Division of Nephrology, University of Alabama at Birmingham, 1720 2nd Ave. South, Zeigler Research Building 524, Birmingham, AL 35294-0007, USA


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© Timmy Lee; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Medicine, Division of Nephrology, University of Alabama at Birmingham, 1720 2nd Ave. South, Zeigler Research Building 524, Birmingham, AL 35294-0007, USA; Tel: 205-975-9322; Fax: 205-996-6465; E-mail: txlee@uab.edu


Abstract

The vascular access serves as the “lifeline” for the hemodialysis patient, but in recent years has become the “Achilles Heel” of the hemodialysis procedure. The vascular health of the vessels used to create arteriovenous accesses is paramount to vascular access maturation and successful outcomes. Vascular calcification is widely present in the vessels of chronic kidney disease (CKD) and end stage renal disease (ESRD) patients, and may also potentially impact the vascular access remodeling process. Few studies have been published to date evaluating vascular calcification as it relates to vascular access outcomes. However, an improved understanding of how vascular calcification plays a pathophysiological role in hemodialysis vascular access dysfunction may improve therapies to treat arteriovenous fistula (AVF) non-maturation and the health of the vessels prior to vascular access creation.

Keywords: Arteriovenous fistula, chronic kidney disease, hemodialysis vascular access dysfunction, vascular calcification..