RESEARCH ARTICLE


Colistin Induced Neurotoxicity in a Patient with End Stage Kidney Disease and Recovery with Conventional Hemodialysis



Radhika Chemmangattu Radhakrishnan*, Shibu Jacob, Harish Ratnakarrao Pathak , Veerasami Tamilarasi
Department of Nephrology, Christian Medical college, Vellore, Tamil Nadu, 632004, India


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Creative Commons License
© Chemmangattu Radhakrishnan et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Nephrology, Christian Medical college, Vellore, Tamil Nadu, 632004, India; Tel: 0416-2282053; Fax: 0416-2232305; E-mail: radhikacr999@gmail.com


Abstract

Colistin is widely used in the treatment of multidrug resistant bacterial infections. Nephrotoxicity and neurotoxicity are risks associated with colistin use. We report the case of a 50 year old lady with end stage renal disease, treated with colistin for catheter related blood stream infection and developed muscle weakness and parasthesia. Concomitant use of meropenem may have precipitated neurotoxicity of colistin. Conventional hemodialysis was effective in reversing her signs and symptoms. Clinicians should be aware of the risk of neurotoxicity while using colistin, especially after a loading dose in patients with renal impairment. According to our knowledge, this is the first report of conventional hemodialysis reversing the neurotoxic effects of colistin.

Keywords: Colistin, end stage kidney disease, hemodialysis, neurotoxicity, side effects.