RESEARCH ARTICLE


Fatal Lactic Acidosis Associated with Lymphoma, Interferon and Ribavirin§.



Vidula T. Vachharajani 1, Tushar J. Vachharajani* , 1, 2
1 Louisiana State University Health Sciences Center
2 Overton Brooks Veterans Affairs Medical Center Shreveport, LA, USA


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© Vachharajani and Vachharajani; Licensee Bentham Open.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

* Address correspondence to this author at the Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA; Tel: 336 716 8341; Fax: 336 716 4318; E-mail: tvachhar@wfubmc.edu


Abstract

Severe lactic acidosis in malignancies is a rare and fatal complication. We report a 51-yr male who presented with fever, fatigue and syncopal episodes and with past medical history of non-Hodgkin’s lymphoma in remission for 3 years, and hepatitis C. He developed severe lactic acidosis and eventually succumbed despite adequate and timely interventions. The clinical presentation resulting from the recurrence of non-Hodgkin’s lymphoma was evident from the initial dramatic response to steroid therapy and confirmed subsequently on histopathology. Mitochondrial toxicity from recent use of peg-interferon and ribavirin possibly contributed to the severity of lactic acidosis.

Keywords: : Lactic acidosis, lymphoma, peg-interferon..