Fatal Lactic Acidosis Associated with Lymphoma, Interferon and Ribavirin.

Vachharajani , Vidula T.; Vachharajani, Tushar J.

Fatal Lactic Acidosis Associated with Lymphoma, Interferon and Ribavirin§.

Vidula T. Vachharajani ¹, Tushar J. Vachharajani^{*
, 1, 2}

¹ Louisiana State University Health Sciences Center

² Overton Brooks Veterans Affairs Medical Center Shreveport, LA, USA

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Identifiers and Pagination:

Year: 2008
Volume: 1
First Page: 38
Last Page: 39
Publisher ID: TOUNJ-1-38
DOI: 10.2174/1874303X00801010038

Article History:

Received Date: 13/8/2008
Revision Received Date: 7/10/2008
Acceptance Date: 12/11/2008
Electronic publication date: 15/12/2008
Collection year: 2008

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© Vachharajani and Vachharajani; Licensee Bentham Open.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

^* Address correspondence to this author at the Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA; Tel: 336 716 8341; Fax: 336 716 4318; E-mail: tvachhar@wfubmc.edu

Severe lactic acidosis in malignancies is a rare and fatal complication. We report a 51-yr male who presented with fever, fatigue and syncopal episodes and with past medical history of non-Hodgkin’s lymphoma in remission for 3 years, and hepatitis C. He developed severe lactic acidosis and eventually succumbed despite adequate and timely interventions. The clinical presentation resulting from the recurrence of non-Hodgkin’s lymphoma was evident from the initial dramatic response to steroid therapy and confirmed subsequently on histopathology. Mitochondrial toxicity from recent use of peg-interferon and ribavirin possibly contributed to the severity of lactic acidosis.

Keywords: : Lactic acidosis, lymphoma, peg-interferon..

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RESEARCH ARTICLE

Fatal Lactic Acidosis Associated with Lymphoma, Interferon and Ribavirin§.

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