REVIEW ARTICLE


Blood Cell Proteomics in Chronic Kidney Disease



Mario Bonomini1, *, Luisa Pieroni2, Maurizio Ronci2, 3, Vittorio Sirolli1, Andrea Urbani4, 5
1 Department of Medicine and Aging Sciences, University “G. D’Annunzio” of Chieti-Pescara, Via dei Vestini, 66100, Chieti, Italy
2 IRCCS-Santa Lucia Foundation, Rome, Italy
3 Department of Medical, Oral and Biotechnological Sciences, University “G. D’Annunzio” of Chieti-Pescara, Chieti, Italy
4 Institute of Biochemistry and Clinical Biochemistry, School of Medicine - Catholic University, Rome, Italy
5 Fondazione Policlinico Gemelli-IRCCS, Clinical Chemistry UOC, Rome, Italy


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© 2018 Bonomini et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Medicine and Aging Sciences, University “G. D’Annunzio” of Chieti-Pescara, Via dei Vestini, 66100, Chieti, Italy; Tel: +390871540120; E-mail: m.bonomini@nephro.unich.it


Abstract

Background:

The uremic syndrome mimes a systemic poisoning with the retention of numerous compounds which are normally removed by the kidney. The study of proteins and peptides, or proteomics, represents an important field of research for the investigation of blood and blood diseases.

Methods and Materials:

We focused our review on the results of proteomic investigations on blood cells of uremic patients with particular regard to the study of red blood cells, platelets, and monocytes.

Results:

In literature there are few, preliminary studies on platelets and monocytes while the knowledge on uremic erythrocytes is much wider. Proteomic investigations showed that erythrocyte membrane proteome of uremic patients, differs significantly from the proteome of healthy subjects, being characterized by an extensive remodeling which may influence visco-elastic properties of RBC such as deformability and involve diverse molecular pathways driving red blood cell signaling and removal.

Conclusion:

Proteomic technologies emerged as a useful tool in defining and characterizing both physiological and disease processes being able, among others, to give important insights into uremic anemia.

Keywords: Chronic kidney disease, Proteomic, Red blood cell, Platelet, Monocyte, Anemia, Hemodialysis.