REVIEW ARTICLE


The Use of Peri-operative Tranexamic Acid and its Potential Applications to Urological Surgery



Jeremy Nettleton1, *, Anthony Adimonye1, Jonathan Manley2, Joseph Jelski1, Warren Doherty3, Mandy Rees3, Biral Patel1
1 Department of Urology, Cheltenham General Hospital, Cheltenham, UK
2 Department of Urology, Pinderfields Hospital, Wakefield, UK
3 Department of Anaesthesia, Cheltenham General Hospital, Cheltenham, UK


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© 2018 Nettleton et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Urology, Cheltenham General Hospital, Cheltenham, UK; Tel: 07779 250 534; E-mail: jeremy.nettleton@nhs.net


Abstract

Tranexamic acid has been shown to be an effective agent in reducing blood loss in various surgical procedures; however, there is a dearth of evidence for its use and potential side effects in urological surgical procedures. This review discusses the pathophysiology of tranexamic acid, its use in traumatic and surgical bleeding and the current evidence for its potential utilisation in urological surgery.

Keywords: Tranexamic acid, Anti-fibrinolytic, Blood loss, Transfusion rate, Urological surgery, Surgical bleeding.