Bacillus Calmette-Guérin Perfusion Treatment via Cutaneous Ureterostomy for Carcinoma in Situ of the Upper Urinary Tract

Tatsuya Umemoto1, Kazuya Oda1, Tatsuo Kano1, Hakushi Kim1, Hidenori Zakoji1, *, Akira Miyajima1
1 Department of Urology, Tokai University Hachioji Hospital 1838 Ishikawa-machi, Hachioji, Tokyo 192-0032, Japan

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© 2021 Umemoto et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at Department of Urology, Tokai University Hachioji Hospital, 1838 Ishikawa-machi, Hachioji, Tokyo 192-0032, Japan; Tel: 81-42-639-1111; Fax: 81-42-639-1144; E-mail:



Bacillus Calmette-Guérin instillation is an established therapy for the treatment of carcinoma in situ of the upper urinary tract.

Case Presentation:

A 72-year-old woman underwent radical cystectomy with cutaneous ureterostomy for invasive bladder cancer with carcinoma in situ of both ureters. For the treatment of upper urinary tract carcinoma in situ, an infusion of 40 mg bacillus Calmette-Guérin through each ureterostomy was performed once weekly for 5 times. Urine cytology of the left upper urinary tract became negative, with a recurrence-free survival of 4 months. On the other hand, the right upper urinary tract became temporarily negative but turned positive after 3 months.


Bacillus Calmette-Guérin perfusion therapy via cutaneous ureterostomy is considered as one of the useful therapies for carcinoma in situ of the upper urinary tract. Furthermore, there are several factors to be discussed, including the treatment duration, dosage and secondary therapeutic options.

Keywords: Bacillus calmette-Guérin, Carcinoma in situ, Cutaneous ureterostomy, Radical cystectomy, Upper urinary tract, Magnetic resonance imaging.